The density and distribution of serotonergic appositions onto identified neurons in the rat rostral ventromedial medulla
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چکیده
منابع مشابه
A confocal laser microscopic study of enkephalin-immunoreactive appositions onto physiologically identified neurons in the rostral ventromedial medulla.
Neurons in the rostral ventromedial medulla (RVM) are important in the opioid modulation of dorsal horn nociceptive transmission. Systemically administered morphine inhibits one class of RVM cells, the on-cells; excites a second class of RVM cells, the off-cells; and has no effect on a third class, neutral cells. In contrast, iontophoretic application of morphine inhibits on-cells but does not ...
متن کاملElectrophysiological heterogeneity of spinally projecting serotonergic and nonserotonergic neurons in the rostral ventromedial medulla.
This study examined the passive membrane and action potential properties of serotonergic and nonserotonergic neurons in the rostral ventromedial medulla (RVM) of the rat using whole cell patch-clamp recording techniques in the slice. Serotonergic neurons were identified by immunoreactivity for tryptophan hydroxylase (TrpH). Spinally projecting neurons were retrogradely labeled with 1'-dioactade...
متن کاملorexin-a modulates firing of rat rostral ventromedial medulla neurons: an in vitro study
the rostral ventromedial medulla (rvm) acts a key role in the descending inhibitory pain modulation. neuropeptide orexin-a (orxa) is confined to thousands of neurons in the lateral hypothalamus (lh). while rvm gets the orexinergic projections, the orexin receptors are also expressed in this structure. the aim of this study was to specify the cellular effects of orxa on rvm neurons in vitro by u...
متن کاملOpioid receptor modulation of GABAergic and serotonergic spinally projecting neurons of the rostral ventromedial medulla in mice.
The rostral ventromedial medulla (RVM) is an important site of opioid actions and forms part of an analgesic pathway that projects to the spinal cord. The neuronal mechanisms by which opioids act within this brain region remain unclear, particularly in relation to the neurotransmitters GABA and serotonin. In the present study, we examined serotonergic and GABAergic immunoreactivity, identified ...
متن کاملAdministration of orexin receptor 1 antagonist into the rostral ventromedial medulla increased swim stress-induced antinociception in rat
Objective(s): Intracerebroventricular injection of orexin-A (hypocretin-1) antagonist has been shown to inhibit stress-induced analgesia. However the locations of central sites that may mediate these effects have not been totally demonstrated. This study was performed to investigate the role of rostral ventromedial medulla (RVM) orexin receptor 1 in stress-induced analgesia (SIA). Materials and...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1995
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.15-05-03273.1995